Enzo Maresca's first pre-season period as Chelsea boss has suffered severe disruption owing to Enzo Fernandez, who came under fire for signing an offensive chant about French people after Argentina's Copa America success.
The same goes for Cole Palmer, Conor Gallagher, Moises Caicedo, Euro 2024 winner Marc Cucurella and USA Olympian Gabriel Slonina, but Serbia's Djordje Petrovic and Ukraine's Mykhaylo Mudryk might be involved after their early Euros exits.
Maresca will presumably need to take extra care over Robert Sanchez and Nicolas Jackson, who have been recuperating from injuries over the summer and may therefore not be risked from the start.
As a result, Kepa Arrizabalaga could man the six-yard box after his Real Madrid loan, while Tosin Adarabioyo could make his debut in defence alongside Levi Colwill, Reece James and Axel Disasi.
Newly-acquired midfielders Renato Veiga and Kiernan Dewsbury-Hall are another two who might earn their baptisms on Wednesday, just behind Christopher Nkunku in the number 10 slot.
Ex-Barcelona attacker Marc Guiu could complete the wave of debutants at Levi's Stadium, flanked by Noni Madueke and Raheem Sterling, who has a point to prove after his Euro 2024 snub.
Chelsea possible starting lineup:
Kepa; James, Disasi, Adarabioyo, Colwill; Dewsbury-Hall, Veiga; Madueke, Nkunku, Sterling; Guiu